Biol Reprod Track the topics, authors and articles important to you
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by PURVIS, K.
Right arrow Articles by HANSSON, V.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by PURVIS, K.
Right arrow Articles by HANSSON, V.
Agricola
Right arrow Articles by PURVIS, K.
Right arrow Articles by HANSSON, V.

Biology of Reproduction, Vol 20, 304-309, Copyright © 1979 by Society for the Study of Reproduction

Androgen Effects on Rat Leydig Cells

K. PURVIS 1, O. P.F. CLAUSEN 2, , and V. HANSSON 1

1 Institute of Pathology, Rikshospitalet, Oslo 1, Norway
2 Department of Forensic Medicine Rikshospitalet, Oslo 1, Norway


Treatment of hypophysectomized, 30-day-old male rats with 5 mg dihydrotestosterone propionate (DHTP) or testosterone propionate (TP) daily for 5-6 days resulted in a marked reduction in the magnitude of the maximum steroidogenic response of Leydig cells to hCG. This effect was not mediated through alterations in the LH receptor binding to testicular particles and did not represent a direct competitive inhibition of the steroidogenic enzymes.

The possible involvement of androgens in a ultra-short loop negative feedback on steroidogenesis is discussed in relation to the phenomenon of Leydig cell desensitization.

Note:
ACKNOWLEDGMENTS We thank the WHO, The Population Coucil (New York), the Norwegian Council for Science and the Humanities and the Norwegian Society for Fighting Cancer for financial support. We thank P. Torjesen and NIAMDD for the gifts of LH. We also thank Anita Olsen and Drude Andersen for skilled technical help.

Submitted on May 31, 1978
Accepted on August 1, 1978






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1979 by the Society for the Study of Reproduction.