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Biology of Reproduction, Vol 20, 727-732, Copyright © 1979 by Society for the Study of Reproduction

The Effect of Light on the Prolactin Surges of Pseudopregnant and Ovariectomized, Estrogenized Rats

D. R. PIEPER 1, and R. R. GALA 1

1 Wayne State University School of Medicine, Department of Physiology, Detroit, Michigan 48201


The role of light in the regulation of the prolactin surges of the female rat was investigated. Two model systems were utilized: one was the pseudopregnant rat which normally has 2 daily prolactin surges and the other was the ovariectomized (OVX) polyestradiol phosphate (PEP)-treated rat which normally has a daily afternoon prolactin surge. A 6 h phase advance of the 14 h:10 h photoperiod phase advanced the prolactin surges of pseudopregnant and OVX+PEP rats a corresponding 6 h. Blinded pseudopregnant and OVX+PEP rats had prolactin surges which were free running with respect to time of day, but the maximum values were similar to sighted 14 h:10 h controls. Pseudopregnant or OVX+PEP animals maintained on constant light also had free running prolactin rhythms, but the maximum prolactin values were significantly less than 14 h:10 h controls. Pinealectomy had no effect on the prolactin values of pseudopregnant rats maintained on constant light. It was concluded that the prolactin surges of pseudopregnant and OVX+PEP rats are endogenous circadian rhythms which can be entrained to an exogenous light-dark cycle.

Note:
ACKNOWLEDGMENTS The authors appreciate the excellent technical assistance of Mrs. Cynthia Van De Walle and Mrs. Mee-Ling Chin. Appreciation is also extended to NIAMDD for providing the rat prolactin for standards and iodination.

Submitted on August 23, 1978
Accepted on October 16, 1978




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Copyright © 1979 by the Society for the Study of Reproduction.