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Biology of Reproduction, Vol 21, 57-68, Copyright © 1979 by Society for the Study of Reproduction
1 Department of Animal Science,
Iowa State University,
Ames, Iowa 50011 Porcine relaxin (600 U/day) was injected i.m. into intact and luteectomized Yorkshire pigs late
in gestation in an attempt to elucidate physiological roles of relaxin in cervical dilatation, parturition and lactation. Porcine relaxin, given daily beginning either 105 or 107 days after mating and
before surgical enucleation of corpora lutea (luteectomy) on Day 110, significantly a) induced
premature cervical dilatation, b) decreased the interval from surgery to delivery of the first neonate
and c) reduced duration of delivery of all neonates in the litter compared with those parameters in
luteectomized controls. Exogenous relaxin did not reduce peripheral serum progesterone concentrations and endogenous relaxin activity of the corpora lutes during late pregnancy. Although
porcine corpora lutea secrete progesterone and accumulate relaxin after a prolonged period in
hysterectomized pigs, there was no indication that exogenous relaxin reduced ovarian progesterone
secretion. Lactation was reduced severely in intact and luteectomized dams given porcine relaxin
during an extended period in late pregnancy and resulted in a severe reduction in litter survival to
weaning.
Note:
ACKNOWLEDGMENTS
We thank Dr. W. P. Switzer, Dr. D. O. Farrington
and Dr. K. S. Preston of the Veterinary Medical
Research Institute for monitoring the health status of
the experimental animals, Dr. R. M. Melampy for
advice, Dr. D. F. Cox of the Department of Statistics
for assistance on statistical analyses and Messrs. M. E.
Shell, D. L. Hard and L. S. Carpenter for technical
assistance. Purified porcine relaxin (CM-B) was generously provided by Dr. B. G. Steinetz, Research Department, Pharmaceuticals Division, CIBA-GEIGY Corp.,
Ardsley, NY and purified porcine relaxin (NIH-R-P1)
from NIH, Bethesda, MD. Antiserum to progesterone
(GDN #337) was generously supplied by Dr. G. D.
Niswender, Department of Physiology and Biophysics,
Colorado State University, Fort Collins.
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J. A. Lenhart, P. L. Ryan, K. M. Ohleth, S. S. Palmer, and C. A. Bagnell Relaxin Increases Secretion of Matrix Metalloproteinase-2 and Matrix Metalloproteinase-9 during Uterine and Cervical Growth and Remodeling in the Pig Endocrinology, September 1, 2001; 142(9): 3941 - 3949. [Abstract] [Full Text] [PDF]
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