Biol Reprod Lalor Postdoctoral Fellowships -- Application Deadline January 15, 2009
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by STONE, G. M.
Right arrow Articles by MILLER, B. G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by STONE, G. M.
Right arrow Articles by MILLER, B. G.
Agricola
Right arrow Articles by STONE, G. M.
Right arrow Articles by MILLER, B. G.

Biology of Reproduction, Vol 21, 273-280, Copyright © 1979 by Society for the Study of Reproduction

The Uterine Endometrium and Isthmic Oviduct of the Ewe: Does Progesterone Act as an Antiestrogen?

G. M. STONE 1, JENNIFER WILD , , and B. G. MILLER 2

1 Department of Veterinary Physiology, University of Sydney, N.S.W. 2006, Australia
2 Department of Animal Husbandry, University of Sydney, N.S.W. 2006, Australia


The action of progesterone (P) on the estrogen stimulated uterine endometrium and isthmic oviduct of the ewe was studied. Changes in protein:DNA and RNA:DNA ratios, rate of in vitro protein synthesis, alkaline phosphatase and peroxidase activity and the level of cytoplasmic receptors for estradiol (E2) and P were measured in the endometrium. Only receptor effects were measured in the oviduct. Progesterone decreased the level of both receptors in each tissue but did not decrease protein:DNA and RNA:DNA ratios or protein synthesis; P had little effect on alkaline phosphatase activity and there was no detectable peroxidase activity.

These findings argue against the concept, based on studies in the rat, that the initial antiestrogenic effects of P are mediated by a specific effect on E2 receptor replenishment.

Note:
ACKNOWLEDGMENTS This study was aided by the Australian Research Grants Committee. The authors are grateful to Ms. Anne Budden and Misses R. Mayo-Ramsay and M. Abbott for their valuable technical assistance.

Submitted on December 26, 1978
Accepted on April 16, 1979






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1979 by the Society for the Study of Reproduction.