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Biology of Reproduction, Vol 21, 339-346, Copyright © 1979 by Society for the Study of Reproduction

Maintenance of Unimplanted Fertilized Ova in Spayed Rats. I. Effects of Laparotomy, Ligation of the Uterine Cervix, Ligation of the Ovarian Blood Vessels, Progesterone Therapy and the Implantation-Inducing Hormonal Regimen

J. G. POWELL JR. 1, D. R. BENNETT 1, , and R. L. COCHRANE 1

1 The Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46206


Studies were carried out to determine whether implantation of ova could be obtained after a period of ovarian hormone deprivation that extended from Day 3 through Day 8 of pregnancy in the spayed rat. The effects of such factors as some common surgical procedures and the implantation inducing hormonal regimen were also investigated.

A very low incidence of ovo-implantation was obtained in spayed rats that received no hormone therapy until Day 9 of pregnancy, whether the subsequent treatment was 4 mg progesterone plus 1 µg estrone/day (P + E) alone, or 1, 2 or 3 days of treatment with 4 mg progesterone (P) preceding treatment with P + E. In contrast, spayed animals given P from Day 2 through Day 8, had a high incidence of ovo-implantation in response to subsequent treatment with P + E. Ligation of the uterine cervices on Day 3, omission of a laparotomy on Day 8, or omission of the ovarian blood vessel ligation at ovariectomy (on Day 3) had little or no effect on the low incidence of ovo-implantation obtained in the spayed rats that received no hormone therapy until Day 9. However, ligation of the uterine cervices on Day 3 slightly reduced and omission of the ovarian blood vessel ligation increased the incidence of implantation in the spayed rats treated from Day 2 through Day 8 with P.

 Submitted on December 22, 1978
Accepted on May 12, 1979






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Copyright © 1979 by the Society for the Study of Reproduction.