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Biology of Reproduction, Vol 21, 379-383, Copyright © 1979 by Society for the Study of Reproduction

Acute and Chronic Morphine Sulfate Treatment Alters Ovarian Development in Prepuberal Rats

SUE LINTERN-MOORE 1, YINDEE SUPASRI 2, K. PAVASUTHIPAISIT 2, , and P. SOBHON 2

1 School of Biological Sciences, Macquarie University, North Ryde, 2113, New South Wales, Australia
2 Department of Anatomy, Mahidol University, Bangkok IV, Thailand


Morphine sulfate administered i.p. (50 mg/kg BW/day) to immature 21-day-old rats for 1 or 7 days alters ovarian follicular development without inhibiting the total body weight or the growth of the ovary, uterus, pituitary or adrenal. The acute effect of a single dose of morphine reduced the number of follicles initiated to grow without altering the number or size distribution of follicles in other growth compartments. Chronic daily administration of morphine for 7 days sustained the reduction in the initiation of follicular growth and reduced the number of follicles in growth compartments up to early antrum formation, This specific effect of morphine sulfate is discussed in relation to the role of gonadotropins in the maintenance and initiation of follicular growth and the known effect of morphine sulfate on circulating FSH and LH levels.

Note:
ACKNOWLEDGMENTS This study was supported, in part, by a grant to SL-M by the Clive and Vera Ramaciotti Foundations, N.S.W., Australia. Robyn Carr provided excellent technical assistance.

Submitted on February 19, 1979
Accepted on April 16, 1979




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