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Biology of Reproduction, Vol 21, 447-453, Copyright © 1979 by Society for the Study of Reproduction

Cyclic Fluctuations in Ovarian FSH-Inhibiting Material in Golden Hamsters

SCOTT C. CHAPPEL 1

1 Reproductive Physiology, Oregon Regional Primate Research Center, Beaverton, Oregon 97005


Relative amounts of inhibin were measured in charcoal treated ovarian extracts (CTOE) collected on each day of the hamster estrous cycle. This material was quantitated by its ability to depress serum FSH, without affecting LH levels in ovariectomized hamsters. Injection of proestrous CTOE caused a significant reduction in the elevated levels of serum FSH within 2 h. No decrement in serum FSH concentrations was observed in hamsters injected with CTOE collected on other days of the cycle. Further or sustained decreases in serum FSH concentrations were observed when hamsters were administered proestrous CTOE in larger or multiple injections, respectively. None of these injected extracts elicited any change in serum LH levels.

In addition, repeated injections of proestrous CTOE to cyclic hamsters on proestrus and estrus caused a significant reduction in the serum concentration of FSH on estrus compared with control animals. This decrease in estrous FSH was accompanied by a reduction in the number of tubal ova shed 4 days later on the next estrus.

 Submitted on December 8, 1978
Accepted on April 27, 1979






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Copyright © 1979 by the Society for the Study of Reproduction.