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Biology of Reproduction, Vol 21, 1009-1013, Copyright © 1979 by Society for the Study of Reproduction

Impaired Preparturitional Rise of Plasma Estradiol in Aging C57BL/6J Mice

CHRISTIAN F. HOLINKA 1, YUEH-CHU TSENG 1, , and CALEB E. FINCH 1

1 The Andrus Gerontology Center and The Department of Molecular Biology, University of Southern California, Los Angeles, California 90007


The Preparturitional rise of plasma estradiol (E2) was delayed and reduced in aging (11-12 month-old) C57BL/6J mice. In young mice (3-7-month-old), plasma E2 increased up to 3-fold after Day 17 of pregnancy, whereas in older mice the E2 increase was delayed by 1 day or more and never reached the E2 levels of young mice. During Days 1-17, no age differences in E2 were detected. Previously, we showed that the normal preparturitional decrease of plasma progesterone (P) was slowed in the same older mice studied here. The impaired regulation of E2 and P may be factors in the 2 day (mean) prolongation of pregnancy observed in these older mice (Holinka et al., 1978).

Note:
ACKNOWLEDGMENTS We are pleased to acknowledge valuable assistance in statistical analysis from Patrick Randall, Phyllis Amaral, Donna Ringering and James Severson. This research was supported by grants to C.E.F. from NIH (AG-00117, AG-00446 and AG-007670) and by NIMH training grant ST-22NH00070. A part of this work was done with the support of a Population Council Postdoctoral Fellowship to C.F.H.

Submitted on February 22, 1979
Accepted on August 11, 1979






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Copyright © 1979 by the Society for the Study of Reproduction.