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Biology of Reproduction, Vol 21, 765-772, Copyright © 1979 by Society for the Study of Reproduction
1 Division of Reproductive Biology, Department of Population Dynamics,
The Johns Hopkins School of Hygiene and Public Health,
Baltimore, Maryland 21205 Simultaneous administration of specific doses of testosterone and estradiol via subdermal
Silastic implants created a reversible azoospermia in male rats without increasing the seminal
vesicle and ventral prostate weights or serum concentrations of testosterone and estradiol (Ewing
et al., 1977). Herein we report that a single implantation of 2.5 cm testosterone and 0.1 cm estradiol subdermal polydimethylsiloxane (PDS, Silastic) capsules rendered male rats reversibly sterile
for 8 months. The onset or cessation of sterility occurred abruptly 6 weeks following either the
implantation or removal of steroid filled capsules, respectively. This reversible sterility was attained
without any significant change in either masculine sex behavior or shock induced aggressive behavior.
2 Department of Anatomy, UCLA School of Medicine,
Los Angeles, California 90024
3 Department Psychiatry/Biobehavioral Sciences,
Neuropsychiatric Institute, UCLA School of Medicine,
Los Angeles, California 90024
4 Department of Psychology, University of California,
Los Angeles, California 90024
5 Department of Zoology, University of Texas, Austin
Austin, Texas 78712
6 Department of Pharmacology and Therapeutics and Department of Obstetrics and Gynecology, McGill University, Montreal, Canada
Accepted on July 5, 1979
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