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Biology of Reproduction, Vol 21, 867-872, Copyright © 1979 by Society for the Study of Reproduction

Changes in Concentrations of Circulating Gonadotropins following Administration of Equine Follicular Fluid to Ovariectomized Mares

KURT F. MILLER 1, J. A. WESSON 1, , and O. J. GINTHER 1

1 Department of Veterinary Science, University of Wisconsin, Madison, Wisconsin 53706


The effects of administration of equine follicular fluid (FF) on gonadotropin concentrations in the ovariectomized (OVX) mare were examined. The FF was obtained by aspiration of follicles in ovaries obtained during the summer at a slaughterhouse. Systemic administration of whole equine FF to OVX mares resulted in significant decreases in circulating concentrations of FSH (26.0-74.0% of the pretreatment concentrations depending on dosage). Treatment with FF from which steroids had been removed tended (P<0.10) to decrease FSH. Treatment with either a steroid fraction alone or a steroid fraction with denatured proteins had no effect (P>0.10) on FSH. Treatment with whole FF initially decreased and then increased the concentrations of LH. It was concluded that the equine FF contained a nonsteroidal substance that has FSH suppresing properties.

Note:
ACKNOWLEDGMENTS This work was supported by the College of Agricultural and Life Sciences and the Graduate School, University of Wisconsin, Madison. The anti-human FSH used in the FSH assay was a gift of NIAMDD. The authors express their appreciation to Meat-X Corporation, Milwaukee, WI, for allowing collection of ovaries. The authors thank Dr. B. C. Wentworth for helpful advice and Mr. T. E. Ladell for excellent technical assistance.

Submitted on April 10, 1979
Accepted on August 4, 1979




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Copyright © 1979 by the Society for the Study of Reproduction.