Biol Reprod Keystone Symposia Conference on Frontiers in Reproductive Biology & Regulation of Fertility.
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Biology of Reproduction, Vol 21, 909-922, Copyright © 1979 by Society for the Study of Reproduction

Ultrastructural Differentiation of Rat Sertoli Cells

ANGEL S. RAMOS JR. 1, and MARTIN DYM 2

1 Department of Veterinary Science, Electron Microscope Laboratory, University of Nebraska, Lincoln, Nebraska 68583
2 Department of Anatomy and Laboratory of Human Reproduction and Reproductive Biology, Harvard Medical School, Boston, Massachusetts 02115


Fine structural cytodifferentiation of the Sertoli cells of the rat testis was examined at 2 week intervals from Day 7 postnatally to sexual maturity. The cells undergo rapid morphological differentiation during the first 5 weeks after birth. These changes include a large increase in cell size and in the extent of cytoplasmic processes between germinal cells; changes occur in the pattern of nuclear chromatin condensation and nuclear envelope infoldings and in the development of cellular organelles, particularly the smooth endoplasmic reticulum, Golgi apparatus and mitochondria. Differentiation of the basal cytoplasm consists primarily of a regional accumulation of microtubules and microfilaments, whereas apical surface specializations consist of fingerlike cytoplasmic projections. An apparent sequence of events was observed in the development of the junctional complexes between neighboring cells and in the formation of the tripartite nucleolus. This Sertoli cell structural differentiation occurring during the prepuberal period correlates with the appearance of various physiologic and metabolic changes in the function of the developing testis.

Submitted on April 10, 1979
Accepted on August 10, 1979




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Endocrinology, July 1, 2005; 146(7): 2992 - 3004.
[Abstract] [Full Text] [PDF]


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Copyright © 1979 by the Society for the Study of Reproduction.