Biol Reprod Track the topics, authors and articles important to you
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow My Folders
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by PELUSO, J. J.
Right arrow Articles by STEGER, R. W.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by PELUSO, J. J.
Right arrow Articles by STEGER, R. W.
Agricola
Right arrow Articles by PELUSO, J. J.
Right arrow Articles by STEGER, R. W.

Biology of Reproduction, Vol 21, 929-936, Copyright © 1979 by Society for the Study of Reproduction

Effects of Cyproterone Acetate, a Potent Antiandrogen, on the Preovulatory Follicle

J. J. PELUSO 1, I. BROWN 1, , and R. W. STEGER 2

1 Department of Biology, Loyola University of Chicago, Chicago, Illinois 60626
2 Department of Physiology, Michigan State University, East Lansing Michigan 48824


The effects of cyproterone acetate, a potent antiandrogen, on preovulatory follicles were studied both in vivo and in vitro. In vivo administration of cyproterone acetate induced acid phosphatase activity and reduced mitosis within the granulosa cell layer, accelerated the rate of atresia and subsequently transformed the preovulatory follicle into an ovarian cyst. Serum LH levels were not altered, but serum FSU levels were initially suppressed by cyproterone acetate treatment. In vitro, cyproterone acetate reduced the number of granulosa cells incorporating [3H]-thymidine by 50%. These observations suggest that androgens are involved in maintaining the preovulatory follicle and that their action is mediated in part by a direct intraovarian mechanism.

Note:
ACKNOWLEDGMENTS The authors are indebted to the Rat Pituitary Program of NIAMDD for providing the rat LH and FSH assay kits and to Dr. F. Neumann of Schering AG for donating the cyproterone acetate. We also thank Mr. David Stude for his excellent technical assistance.

Submitted on April 10, 1979
Accepted on August 15, 1979






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1979 by the Society for the Study of Reproduction.