Biol Reprod Keystone Symposia Conference on Frontiers in Reproductive Biology & Regulation of Fertility.
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Biology of Reproduction, Vol 21, 1087-1090, Copyright © 1979 by Society for the Study of Reproduction

Abnormal Reproductive Development in Rats after Neonatally Administered Antiestrogen (Tamoxifen)

G. C. CHAMNESS 1, G. A. BANNAYAN 2, L. A. LANDRY JR. 3, P. J. SHERIDAN 3, , and W. L. McGUIRE 1

1 Department of Medicine, The University of Texas Health Science Center, San Antonio, Texas 78284
2 Department of Pathology, The University of Texas Health Science Center, San Antonio, Texas 78284
3 Department of Anatomy, The University of Texas Health Science Center, San Antonio, Texas 78284


The antiestrogen tamoxifen, administered to newborn female rats, caused gross abnormalities in reproductive development. Vaginal opening was early, cycles were absent and at 4 months of age all ovaries and uteri were atrophic while oviducts showed severe squamous metaplasia with abscess formation. No overt malignancy was detected at this early age, but these results and similar findings with nafoxidine and clomiphene may suggest caution in the use of antiestrogens and similar compounds during possible pregnancy.

Note:
ACKNOWLEDGMENTS This work was supported by grants from NIH (NS 12933, CB 23862, CA 22343, RCDA 1 KO4 000164, P30 HD 10202) and the Milheim Foundation (76-22).

Submitted on December 19, 1978
Accepted on September 5, 1979






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Copyright © 1979 by the Society for the Study of Reproduction.