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Biology of Reproduction, Vol 21, 1163-1167, Copyright © 1979 by Society for the Study of Reproduction
1 Laboratorio de Endocrinologia,
Instituto de Ciencias Biológicas,
Pontificia Universidad Católica de Chile,
Santiago, Chile The effect of estradiol-17 Estradiol was given as a single s.c. injection on Day 1 of pregnancy. Groups of 5 animals were
sacrificed between 0-94 h following treatment, to determine distribution of eggs in the genital
tract and estradiol levels in plasma. Groups of 15 rats were sacrificed on Day 12 of pregnancy to
determine the number of embryos implanted. Ovum transport through the oviduct was accelerated between 11-23 h following estradiol
injection in all groups: 0.5, 1, 5 or 25 µg estradiol-17 It is concluded that a short pulse of estradiol given on Day 1 of pregnancy in rats accelerates
the transport of ova through the oviduct after a latency period of 11 h. This is followed by an
immediate expulsion of eggs from the tract leading to inhibition of fertility, which is quantitatively
related to the number of ova expelled. Eggs that are not accelerated are transported and develop
and implant normally. The rat can provide a model of fertility inhibition due exclusively to accelerated transport of ova.
on ovum transport in rats was characterized by determining dose-response curve, latency and duration of effect. The relationship between plasma levels of estradiol,
accelerated transport and reduced fertility was also examined. produced acceleration of 25, 80, 90 and
94% of ova that passed prematurely from the oviduct to the uterus, respectively. Nonaccelerated ova were transported to the uterus at the normal time. Accelerated transport through
the oviduct was accompanied by expulsion of eggs through the vagina. The mean number of implanted embryos on Day 12 of pregnancy was almost identical to the mean number of eggs remaining in the tract after the acceleration phase was completed. Maximal levels of estradiol in plasma
were attained 10 h before the onset of acceleration, whereas the return to basal levels bore no
constant relationship to the end of acceleration.
Note:
ACKNOWLEDGMENTS
This investigation was supported by Programa
Latinoamericano de Investigación en Reproducción
Humana (PLAMIRH) Grant No. 42.107. 1.76 to M. E.
Ortiz.
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