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Biology of Reproduction, Vol 22, 155-158, Copyright © 1980 by Society for the Study of Reproduction

Measurement of Estradiol-17beta Dehydrogenase Activity in Rat Endometrium during the Estrous Cycle and the First Half of Pregnancy

0. KREITMANN 1, S. AMR 1, F. BAYARD 1, , and J. C. FAYE 1

1 INSERM U168, Department of Endocrinology, CHU Rangueil, Université Paul Sabatier, Toulouse 31054, France


Estradiol-17beta dehydrogenase (E2DH) activity was measured in the endometrium of immature and of mature rat uteri at different times of the estrous cycle and during the first 10 days of pregnancy. E2DH activity is not detected in immature or castrated mature rats. During the estrous cycle, E2DH activity is 565 ± 103 pmol/mg protein/h (mean ± SEM, n = 7) at proestrus; 479 ± 80 (n = 6) at estrus; 94 ± 18 (n = 6) at metestrus; and 73 ± 12 (n = 6) at diestrus. During pregnancy E2DH activity is 605 ± 97 (n = 6) at P1 (corresponding to the day of estrus). It decreases to 347 ± 76 (n = 6) on P2; 66 ± 10 (n = 6) on P3; 78 ± 17 (n = 14) on P4; and 137 ± 27 (n = 10) on P5. It then increases again to 2246 ± 340 (n = 6) on P6 and stays high until at least P10. Decidualization and the presence of the blastocysts are not necessary for the development of the enzyme activity during pregnancy. Therefore, the interconversion of estradiol-17beta and estrone in rat endometrium is a function of the maturity of the animal, of the stage of the estrous cycle and of the stage of pregnancy.

Note:
ACKNOWLEDGMENTS This work was supported by INSERM and DGRST.

Submitted on August 22, 1979
Accepted on October 31, 1979




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