Biol Reprod Keystone Symposia Conference on Frontiers in Reproductive Biology & Regulation of Fertility.
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Biology of Reproduction, Vol 22, 159-163, Copyright © 1980 by Society for the Study of Reproduction

Induction of Rat Endometrial Estradiol-17beta Dehydrogenase Activity by Estradiol and Progesterone

S. AMR 1, J. C. FAYE 1, F. BAYARD 1, , and O. KREITMANN 1

1 INSERM U168, Department of Endocrinology, CHU Rangueil, Universitè Paul Sabatier, Toulouse 31054, France


Estradiol-17beta dehydrogenase (E2DH) activity in rat endometrium is undetectable in the castrated rat but can be induced by E2 stimulation. When E2 is given alone for 3 days, the E2DH activity induced is linearly related to the logarithm of the dose administered (r = 0.90, P<0.005). Administration of progesterone (P) with the third E2 injection decreases the enzyme activity but a linear relationship is still observed with the logarithm of the dose of E2 administered (r = 0.77, P<0.005). P alone is not able to induce E2DH activity. However, when P is administered for 3 days and E2 is added with the last P injection, the effect of this single dose of E2 is magnified. A time lag is observed between E2 administration and the induction of E2DH activity when the dose of E2 is 0.1 µg. When the single dose of E2 is increased to 2 µg, the time lag is shortened. After induction in these conditions, P alone is able to maintain E2DH activity.

These data indicate that changes in the enzyme activity are under the control of both ovarian hormone E2 and P. They explain precisely the development of endometrial E2DH activity during the first 10 days of pregnancy. They do not explain clearly, however, the variations observed during the estrous cycle, an observation which suggests the intervention of a third factor not yet elucidated.

Note:
ACKNOWLEDGMENTS This work was supported by INSERM and DGRST.

Submitted on August 22, 1979
Accepted on October 31, 1979






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Copyright © 1980 by the Society for the Study of Reproduction.