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Biology of Reproduction, Vol 22, 333-338, Copyright © 1980 by Society for the Study of Reproduction

Active Immunization of Male Rhesus Monkeys against Luteinizing Hormone Releasing Hormone

S. C. CHAPPEL 1, W. E. ELLINWOOD 1, C. HUCKINS 1, D. C. HERBERT 1, , and H. G. SPIES 1

1 Reproductive Physiology, Oregon Regional Primate Research Center, Beaverton, Oregon 97006


After continued immunization of 3 male rhesus monkeys (Macaca mulatta) against luteinizing hormone releasing hormone (LHRH), serum titers of LHRH antibodies rose. When these titers reached an effective level, dramatic decreases in serum concentrations of luteinizing hormone (LH) and testosterone (T) were observed. As antibody levels declined, serum LH and T levels returned to preimmunization values. Repeated immunization throughout a 12 month period caused a decline in testicular weight and steroid production, a decrease in anterior pituitary LH concentrations, a reduction in hypothalamic LHRH content and histological changes within the pituitary and testes. Injection of Freund’s complete adjuvant into 3 other males caused no change in these parameters of reproductive function.

This study has demonstrated the potent inhibitory effects of LHRH immunoneutralization on the integrity of the hypothalamic-pituitary-testicular axis in M. mulatta.

 Submitted on September 17, 1979
Accepted on November 5, 1979




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Copyright © 1980 by the Society for the Study of Reproduction.