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Biology of Reproduction, Vol 22, 805-809, Copyright © 1980 by Society for the Study of Reproduction

Effects of Advancing Age on Hypothalamic-Hypophysial-Testicular Functions in the Male White-footed Mouse (Peromyscus leucopus)

R. W. STEGER 1, H. H. HUANG 1, C. A. HODSON 1, F. C. LEUNG 1, J. MEITES 1, , and G. A. SACHER 1

1 Department of Physiology, Neuroendocrine Research Laboratory, Michigan State University, East Lansing, Michigan 48824


The effects of advancing age on the hypothalamic-hypophysial-testicular axis of the white-footed mouse, Peromyscus leucopus, was investigated because of its relatively long lifespan and reproductive period as compared with the laboratory mouse, Mus musculus. Peromyscus, with an average lifespan of 48 months, showed similar levels of serum luteinizing hormone (LH) and hypothalamic catecholamines from 12 to 42 months of age, but hypothalamic LH-releasing hormone (LHRH) levels decreased between 36 and 42 months. Although not statistically significant, testicular weight and serum testosterone levels decreased progressively after 20 months and were lower at 42 months than at any other age tested. The lack of significant change in these end points is in marked contrast to the aging laboratory rat, but parallels observations in the shorter-lived laboratory mouse.

Submitted on November 19, 1979
Accepted on February 7, 1980




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[Abstract] [Full Text] [PDF]


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Copyright © 1980 by the Society for the Study of Reproduction.