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Biology of Reproduction, Vol 23, 363-368, Copyright © 1980 by Society for the Study of Reproduction

Genetic Variation in the Timing of First Cleavage in Mice: Effect of Paternal Genotype

J. G.M. SHIRE 1, and W. K. WHITTEN 1

1 The Jackson Laboratory, Bar Harbor, Maine 04609


Eggs from SJL x SWR F1 mice (SFF1) that had been fertilized in vivo were cultured in vitro in defined medium. The mean time of first cleavage depended on the strain of male parent. Cleavage occurred in eggs fertilized by BALB/cWt males 4 h later than in eggs fertilized by SFF1 males. Eggs fertilized by SJL or SWR males cleaved at different times, but in both cases later than those fertilized by the F1 hybrids. Measurements on eggs fertilized by males from a pair of stocks consomic for the BALB/cWt or SJL Y chromosomes showed that the genetic determinants of the significantly earlier cleavage caused by SJL males were autosomal rather than Y-linked, and were unrelated to those involved in the production of hermaphrodites. No differences were found between BALB/cBy, C57BL/6By and their recombinant inbred derivative CXBH in their effects on the timing of first cleavage.

Eggs, from SFF1 females, that had completed first cleavage were more likely to form blastocysts when the male was an SSF1 rather than a BALB/cWt mouse.

Note:
ACKNOWLEDGMENTS This research was supported by grant HD-04083 from NIH to W.K.W. J.G.M.S. was a NATO-SRC Senior Visiting Scientist and is grateful to the Wellcome Foundation for a travel grant. The Jackson Laboratory is fully accredited by the American Association for the Accreditation of Laboratory Animal Care.

Submitted on February 1, 1980
Accepted on June 12, 1980




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Copyright © 1980 by the Society for the Study of Reproduction.