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Biology of Reproduction, Vol 23, 404-413, Copyright © 1980 by Society for the Study of Reproduction

Importance of Estradiol and Progesterone in Regulating LH Secretion and Estrous Behavior During the Sheep Estrous Cycle

FRED J. KARSCH 1, SANDRA J. LEGAN 2, KATHLEEN D. RYAN 3, , and DOUGLAS L. FOSTER 4

1 Reproductive Endocrinology Program, Departments of Pathology, and Biological Sciences, The University of Michigan, Ann Arbor, Michigan 48109
2 Department of Physiology and Biophysics, University of Kentucky, Lexington, KY 40536.
3 Department of Physiology, University of Pittsburgh, School of Medicine, Pittsburgh, Pa 15261.
4 Reproductive Endocrinology Program, Departments of Physiology, Obstetrics and Gynecology, and Biological Sciences, The University of Michigan, Ann Arbor, Michigan 48109


Replacement of the ovaries of sheep shortly after ovulation with Silastic implants that simulated the physiological patterns and levels of estradiol and progesterone which circulate during the normal estrous cycle produced an "artificial estrous cycle" in which the time course of serum LH and the incidence of estrous behavior closely resembled those of the normal cycle. Neither steroid by itself was effective in this regard. This suggests that two ovarian steroids, estradiol and progesterone, are both necessary and sufficient to account for the secretion of LH and the expression of estrus during the estrous cycle of sheep.

Note:
ACKNOWLEDGMENTS We are indebted to Douglas Doop for skilled dependable assistance with animal experimentation, and to Barbara Glover and Marjorie Hepburn for conducting radioimmunoassays. We also thank Drs. Gordon D. Niswender and Leo E. Reichert, Jr., for supplying reagents used in radioimmunoassays and Dr. Steven Webel formerly of Abbott Laboratories for donating progesterone implants used to synchronize estrus. We are especially grateful to Robert Kushler, of The University of Michigan Statistical Research Laboratory, for assistance with the statistical analyses.

Submitted on November 30, 1979
Accepted on June 11, 1980




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