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Biology of Reproduction, Vol 23, 423-432, Copyright © 1980 by Society for the Study of Reproduction
1 Laboratoire d’Endocrinologie Expérimentale,
INSERM U 168, CHU Toulouse Rangueil,
31054 Toulouse Cedex During the epididymal transit of spermatozoa, their membranes become coated with glycoproteins, which may play an important role in fertilization. One of these glycoproteins has been
purified from rat epididymides. It has a molecular weight of 37,500 daltons, and an isolectric point
of 4.7. By use of a specific radioimmunoassay, it was shown that this glycoprotein is detected only
in the epididymis and the deferent duct. It is detectable at 20 days of age and increases progressively to reach a plateau between 3 and 4 months of age (15.7 ± 0.9 µg/mg protein, mean ± SD, n =
20). It disappears after castration and reappears after testosterone treatment. Estrogens have
no effect on its production. lmmunohistochemical studies show that it is produced by epithelial
cells of the caput (distal to the initial segment) and of the corpus epididymidis and suggest that its
resorption takes place in the cauda epididymidis and the deferent duct.
2 Laboratoire de Microscopie Electronique,
Faculté de Médecine,
59045 Lille Cedex, France
Note:
ACKNOWLEDGMENTS
This work was supported by a grant from the
French DGRST (no. 77-7.0506) and WHO.
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