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Biology of Reproduction, Vol 23, 487-494, Copyright © 1980 by Society for the Study of Reproduction

Effects of Endotoxin from Different Bacteria on Ovum Transport in Rabbits

MICHAEL J. K. HARPER 1, LENORE WEINBERG 1, ARTURO MORENO 1, , and W. E. FRIEDRICHS 1

1 Center for Research and Training in Reproductive Biology and Voluntary Regulation of Fertility, Department of Obstetrics and Gynecology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas 78284


Endotoxins derived from different bacteria were found to cause accelerated ovum transport in rabbits when administered 24 h after an ovulating injection of hCG. Preparations derived from Salmonella enteritidis, S. typhimurium, and Escherichia coli 0127:B8 were the most potent in this regard. The actions of some of these preparations were prevented by concomitant administration of indomethacin, suggesting a prostaglandin-mediated mechanism of action. This was substantiated by finding increased levels of uterine vein prostaglandins after endotoxin administration. The effect of endotoxin on ovum transport is significant from 18 to 36 h after treatment with hCG, at which time some rabbits are no longer responsive. By 44 h no rabbits responded.

Submitted on May 12, 1980
Accepted on July 2, 1980






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Copyright © 1980 by the Society for the Study of Reproduction.