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Biology of Reproduction, Vol 23, 611-615, Copyright © 1980 by Society for the Study of Reproduction
1 Center for the Study of Aging and Human Development,
Duke University Medical Center, Durham, North Carolina 27710 Serum luteinizing hormone (LH) was measured throughout the afternoon and evening (1500-0130 h) of proestrus in young (4.5 month old) and middle-aged (10.5 month old) female rats
displaying regular 4-day estrous cycles as judged by vaginal smears. An LH surge was measured in
22 of 24 young females. In 20 of the young females, the maximum concentration of LH in the
blood was measured at 1800 h. The LH surge in middle-aged females was more variable in amplitude, and in 21 of the 29 animals in which a surge was observed it occurred at 1930 h or later.
There was a relationship between the time of the surge and its amplitude; "late" surges were
consistently lower. These observations demonstrate that marked changes in the pattern of LH
secretion occur prior to the time ovarian cyclicity ceases in the aging female rat.
2 Center for the Study of Aging and Human Development and Department of Pharmacology,
Duke University Medical Center,
Durham, North Carolina 27710
Accepted on August 5, 1980
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