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Biology of Reproduction, Vol 23, 899-903, Copyright © 1980 by Society for the Study of Reproduction

Relaxin Improves the Coordination of Rat Myometrial Activity in vivo

SANDRA J. DOWNING 1, JANE M. C. BRADSHAW 1, , and D. G. PORTER 1

1 Department of Anatomy, The Medical School, University of Bristol, Bristol BS8 1TD, England, U.K.


The rates of rise or intrauterine pressure cycles recorded from conscious or anesthetized ovariectomized rats were significantly elevated during recovery from total myometrial quiescence imposed by treatment with 5-10 µg porcine relaxin. When uterine activity was provoked by PGF2agr or oxytocin treatment during relaxin inhibition, rates of rise were again increased, although only significantly so in the case of PGF2agr. These data suggest that relaxin may improve myometrial coordination.

Note:
ACKNOWLEDGMENTS We are grateful to Miss Anne Moffatt for skilled technical assistance and to Mrs. S. Somers for typing the manuscript. The project was supported financially by the Agricultural Research Council (Ag 7/77).

Submitted on March 24, 1980
Accepted on August 15, 1980




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