Biol Reprod Keystone Symposia Conference on Frontiers in Reproductive Biology & Regulation of Fertility.
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Biology of Reproduction, Vol 23, 935-940, Copyright © 1980 by Society for the Study of Reproduction

Induced Protein and Deciduoma Formation in Rat Uterus

S. C. BELL 1, J. HAMER 1, , and P. J. HEALD 1

1 Department of Biochemistry, University of Strathclyde, Glasgow G4 ONR, Scotland, U.K.


Using the pregnant rat in which deciduomas were induced by injection of arachis oil into the uterus, it has been found that induced protein (IP) synthesis is greatly increased in the deciduomas. A similar increase was obtained in deciduomas induced in progesterone-maintained ovariectomized animals. The increased synthesis in the pregnant animals was not correlated either with levels of circulating estradiol or the concentration of nuclear estradiol receptor. Synthesis was generally correlated with the degree of cellular mitosis in the uterus.

It is suggested that IP synthesis is suppressed in the uterus on Day 5 of pregnancy, but is released from suppression by the initiation of decidualization. It is also suggested that IP is involved in uterine cell division.

 Submitted on May 30, 1980
Accepted on September 12, 1980






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Copyright © 1980 by the Society for the Study of Reproduction.