Biol Reprod Keystone Symposia Conference on Frontiers in Reproductive Biology & Regulation of Fertility.
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Biology of Reproduction, Vol 24, 528-533, Copyright © 1981 by Society for the Study of Reproduction

Ornithine Decarboxylase Activity in the Artificially Stimulated Decidual Cell Reaction in the Mouse Uterus

SHERRY STINE COLLAWN 1, JUDITH C. RANKIN 1, BARRY E. LEDFORD 1, , and BILLY BAGGETT 1

1 Department of Biochemistry, Medical University of South Carolina, Charleston, South Carolina 29425


Changes in ornithine decarboxylase (ODC) activity in the mouse uterus following stimulation of the decidual cell reaction (DCR) have been examined. ODC activity in the stimulated horn increased sixfold over sham-operated controls 6 h after intraluminal injection of oil. Six hours after trauma stimulation, the activity of ODC in the stimulated horn increased fourfold over contralateral control horns. Indomethacin pretreatment, previously shown to block the oil-stimulated DCR, blocks the increase in ODC activity in the oil-stimulated horn. These results suggest that increased ODC activity is an early event following stimulation of the DCR and may be causally related to the cellular proliferation which occurs as part of the process.

Note:
ACKNOWLEDGMENTS This work was supported by USPHS grant HD-06362 from NICHHD. The authors wish to thank Drs. Jon H. Levine, Helen C. Hamman, and Sylvia A. Braddon for their help in the preliminary stages of this investigation.

Submitted on August 4, 1980
Accepted on December 3, 1980






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Copyright © 1981 by the Society for the Study of Reproduction.