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Biology of Reproduction, Vol 24, 557-564, Copyright © 1981 by Society for the Study of Reproduction

Steroid Hormones and the Metabolism of Oxygen by the Uterus of Pregnant Sheep after Ovariectomy

D. CATON 1, P. S. KALRA 1, C. J. WILCOX 2, , and D. J. HENDERSON 3

1 Department of Anesthesiology, University of Florida College of Medicine, Gainesville, Florida 32610
2 Dairy Science Department, Institute of Food and Agricultural Science, Gainesville, Florida 32610
3 Department of Obstetrics and Gynecology, University of Florida College of Medicine, Gainesville, Florida 32610


Effects of ovariectomy on maternal hormones, on uterine blood flow, and on O2 metabolism of sheep late in gestation were studied. Ovariectomy was associated with lower concentrations of estrone, estradiol, and progestagens in femoral arterial and uterine venous blood and with less variation in the concentration of estrogens, variation which normally is related to day of pregnancy. Birth weight, neonatal weight-gain, and rates of both uterine blood flow and O2 consumption apparently were unaffected, but statistically significant differences were observed in the arterial O2 content and in the fraction of O2 extracted by the uterus. Histologic examination of ovaries during the last half of gestation revealed follicles developing and at least one healthy corpus luteum in every pair of ovaries. This evidence suggests that the ovaries are active, that they contribute to maternal hormonal concentrations, and that they have a measureable effect on patterns of O2 metabolism by the mother.

Note:
ACKNOWLEDGMENTS This research was supported in part by NIH Grant RO1-HD-05659. The authors are indebted to K. Hendricks, W. Betteto, and R. Martin for their technical help, and to Professor L. Larkin of the Department of Anatomy for his help in interpreting the slides.

Submitted on August 26, 1980
Accepted on December 11, 1980






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Copyright © 1981 by the Society for the Study of Reproduction.