Biol Reprod Keystone Symposia Conference on Frontiers in Reproductive Biology & Regulation of Fertility.
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Biology of Reproduction, Vol 24, 643-648, Copyright © 1981 by Society for the Study of Reproduction

Differential Effects of Estradiol-17beta and Progesterone on the Proliferation of Glandular and Luminal Cells of Rabbit Uterine Epithelium

C. J. CONTI 1, I. B. GIMENEZ-CONTI 1, G. O. ZERBE 2, , and L. E. GERSCHENSON 1

1 Department of Pathology, University of Colorado Health Sciences Center, School of Medicine, Denver, Colorado 80262
2 Department of Biometrics, University of Colorado Health Sciences Center, School of Medicine, Denver, Colorado 80262


A technique was developed to determine in vitro the effects of ovarian hormones administered to rabbits on the proliferation of endometrial epithelium. Using this technique, we observed that estradiol-17beta stimulates the proliferation of endometrial glandular cells in intact or ovariectomized rabbits. Progesterone also induced an increase in the proliferation of both luminal and glandular epithelium of intact rabbits. Foci of cells with nuclei labeled with [3H]-Tdr suggesting active hyperplasia were observed in the luminal uterine epithelium of progesterone-treated rabbits, which seems to be related to the formation of glands characteristic of arborized endometrium. Since the ovarian hormones appear to be affecting the luminal and glandular cell populations in different ways, the fact that simultaneous administration of both of them produced a mutual antagonistic effect suggests the existence of complex regulatory mechanisms for the hormonal modulation of proliferation and differentiation in uterine epithelium.

Note:
ACKNOWLEDGMENTS We would like to thank Mrs. R. Lieberman and Mrs. D. Kercheville for their expert help. We also would like to thank Dr. J. T. Murai and Mr. D. Orlicky for critical reading of the manuscript.

Submitted on April 28, 1980
Accepted on December 9, 1980




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B Risek, F. Klier, A Phillips, D. Hahn, and N. Gilula
Gap junction regulation in the uterus and ovaries of immature rats by estrogen and progesterone
J. Cell Sci., January 3, 1995; 108(3): 1017 - 1032.
[Abstract] [PDF]


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Copyright © 1981 by the Society for the Study of Reproduction.