Biol Reprod Keystone Symposia Conference on Frontiers in Reproductive Biology & Regulation of Fertility.
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Biology of Reproduction, Vol 24, 655-659, Copyright © 1981 by Society for the Study of Reproduction

Failure of 5-Thio-D-Glucose to Induce Antispermatogenic Effects in the Musk Shrew, Suncus murinus L

S. K. SINGH 1, and C. J. DOMINIC 1

1 Department of Zoology, Banaras Hindu University, Varanasi 221005, India


The effects of oral administration of 5-thio-D-glucose (50 mg, 100 mg, or 150 mg/kg BW/day, for 30 days) on the male reproductive organs of the musk shrew were investigated. Irrespective of the dose, thioglucose treatment failed to induce regressive changes in the testis and epididymis; in drug-treated shrews both organs exhibited normal histologic features comparable with that of controls. No significant differences between the drug-treated shrews and controls were found in the weights of the testis, epididymis, and accessory sex glands or in protein, RNA, and DNA concentrations in the testis and of fructose in the ampullary gland. The results suggest that the musk shrew testis is insensitive to thioglucose treatment.

Note:
ACKNOWLEDGMENTS The investigation was supported by grants from the Department of Atomic Energy and the Council of Scientific and Industrial Research, Government of India.

Submitted on August 18, 1980
Accepted on October 31, 1980






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Copyright © 1981 by the Society for the Study of Reproduction.