Biol Reprod Keystone Symposia Conference on Frontiers in Reproductive Biology & Regulation of Fertility.
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Biology of Reproduction, Vol 24, 683-689, Copyright © 1981 by Society for the Study of Reproduction

Correlation Between Fetal Weight and Maternal Serum Levels of Murine agr-Fetoprotein and Quantitation of Four Molecular Forms

J. HAU 1, P. SVENDSEN 1, B. TEISNER 2, G. THOMSEN PEDERSON 3, , and BENTE KRISTIANSEN 1

1 Laboratory Animal Unit, University of Odense, 5230 Odense M, Denmark
2 Department of Obstetrics and Gynaecology, University of Sydney, Australia
3 Institute of Obstetrics and Gynaecology, University of Odense, 5230 Odense M, Denmark


Murine agr-fetoprotein (m-AFP) was examined in maternal serum, fetal serum, juvenile serum, amniotic fluid and in whole body homogenates of fetal and juvenile mice.

The maternal serum m-AFP level during pregnancy was significantly correlated with the corresponding fetal weight (r = 0.99, P<0.001). With quantitative crossed concanavalin A (Con A) affino-immunoelectrophoresis, four molecular forms of m-AFP were detected. The levels of the four molecular forms were examined in fetuses and juveniles.

Note:
ACKNOWLEDGMENTS This work was supported by the Danish Research Council (Project No. 512-20084) and the Jubilæumsfond of F. L. Smidth and Co.

Submitted on October 24, 1980
Accepted on November 24, 1980






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Copyright © 1981 by the Society for the Study of Reproduction.