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Biology of Reproduction, Vol 24, 867-869, Copyright © 1981 by Society for the Study of Reproduction
1 Department of Obstetrics and Gynecology and Department of Physiology,
Ralph L. Smith Human Development Research Center,
University of Kansas Medical Center,
Kansas City, Kansas 66103 Implantation in the rabbit occurs between 156-168 h postcoitum (p.c.), and by 175 h p.c.
implanting blastocysts cannot normally be flushed intact from the uterine lumen. The effect of an
intraluminal injection of DL-
-methylhistidine (DL--MH), a specific inhibitor of histidine decarboxylase, on implantation in the rabbit was studied. An intraluminal injection of 2.5 mg of DL--MH at 102 h p.c. interfered with implantation in the rabbit sacrificed at 175 h p.c. Implantation
rates were reduced by more than 60% and this was reflected in the increased number of morphologically expanded normal blastocysts which were flushed from the uterine lumen intact. On the
other hand, the same treatment did not significantly reduce the number of embryos implanted nor
the viability of fetuses when examined on Day 12. However, 4 mg of DL--MH drastically reduced
the implantation rates as well as the viability of the implanted embryos on Day 12. The intraluminal injections of various doses of L-histidine did not significantly affect the implantation rates
or the viability of the fetuses. These results as well as our previous findings suggest that implantation may have been delayed for some time due to inhibition of embryonic histamine synthesis by
DL--MH.
Note:
ACKNOWLEDGMENTS
I thank Miss Cheri Cox for excellent technical
assistance. This research was supported by NICHD
grant (HD-12304).
This article has been cited by other articles:
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  S. R. Hansson, B. Bottalico, V. Noskova, and B. Casslen Monoamine transporters in human endometrium and decidua Hum. Reprod. Update, November 5, 2008; (2008) dmn048v1. [Abstract] [Full Text] [PDF]
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L. Maintz, V. Schwarzer, T. Bieber, K. van der Ven, and N. Novak Effects of histamine and diamine oxidase activities on pregnancy: a critical review Hum. Reprod. Update, September 1, 2008; 14(5): 485 - 495. [Abstract] [Full Text] [PDF]
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 V. Noskova, B. Bottalico, H. Olsson, A. Ehinger, R. Pilka, B. Casslen, and S. R. Hansson Histamine uptake by human endometrial cells expressing the organic cation transporter EMT and the vesicular monoamine transporter-2 Mol. Hum. Reprod., August 1, 2006; 12(8): 483 - 489. [Abstract] [Full Text] [PDF]
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B. Bottalico, R. Pilka, I. Larsson, B. Casslen, K. Marsal, and S. R. Hansson Plasma membrane and vesicular monoamine transporters in normal endometrium and early pregnancy decidua Mol. Hum. Reprod., July 1, 2003; 9(7): 389 - 394. [Abstract] [Full Text] [PDF]
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