Biol Reprod Keystone Symposia Conference on Frontiers in Reproductive Biology & Regulation of Fertility.
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Biology of Reproduction, Vol 24, 871-878, Copyright © 1981 by Society for the Study of Reproduction

Uterine Prostaglandin F2agr Content and 20agr-Hydroxysteroid Dehydrogenase Activity of Individual Ovarian Compartments During Pseudopregnancy in the Rat

JEFFREY A. DOEBLER 1, EDWARD W. WICKERSHAM 1, , and ADAM ANTHONY 1

1 Physiology Section, Department of Biology, The Pennsylvania State University, University Park, Pennsylvania 16802


To investigate relationships between prostaglandin F2agr (PGF2agr) and ovarian 20agr-hydroxysteroid dehydrogenase (20agr-OH SDH), uterine PGF2agr content and ovarian 20agr-OH SDH activity were measured during pseudopregnancy in the rat. Quantitative cytochemical techniques were employed to assess 20agr-OH SDH activity in individual compartments of the rat ovary.

The data indicate appreciable 20agr-OH SDH activity in corpora of pseudopregnancy, in involuting corpora formed in estrous cycles prior to pseudopregnancy, and in the interstitial tissue of the ovary of the pseudopregnant rat. Although enzymatic activity remained unchanged in the latter two compartments between Days 6 and 15 of pseudopregnancy, a twofold elevation in corpora of pseudopregnancy 20agr-OH SDH activity was evidenced between Days 11 and 15. The close temporal relationship between increased uterine PGF2agr content (beginning on Days 9-10, peak on Days 11-12) and increased 20agr-OH SDH activity in corpora of pseudopregnancy provides further evidence implicating PGF2agr as the putative factor responsible for inducing luteal 20agr-OH SDH activity during luteal regression in the rat.

 Submitted on September 29, 1980
Accepted on December 17, 1980






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Copyright © 1981 by the Society for the Study of Reproduction.