Biol Reprod Keystone Symposia Conference on Frontiers in Reproductive Biology & Regulation of Fertility.
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Biology of Reproduction, Vol 25, 120-127, Copyright © 1981 by Society for the Study of Reproduction

Physiological and Pharmacological Characteristics of the Baboon (Papio anubis) Oviduct

A. JOHNS 1, and L. W. COONS 1

1 Center for Research and Training in Reproductive Biology, Department of Obstetrics and Gynecology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas 78284


The pharmacological and electrophysiological characteristics of the oviduct of the preovulatory baboon (Papio anubis) have been investigated. The longitudinal and circular muscle of both isthmus and ampulla contract upon transmural stimulation, and this effect is completely blocked by phentolamine, guanethidine, and tetrodotoxin, suggesting that contractions are mediated by norepinephrine released from adrenergic nerves acting on agr-receptors on the smooth muscle. In circular preparations of the isthmus and in ampulla, nonadrenergic, noncholinergic inhibitory nerves could be demonstrated in the presence of guanethidine. Pharmacologically, the oviductal smooth muscle is contracted by norepinephrine, histamine, acetylcholine, Substance P, 5-hydroxytryptamine, ATP, adenosine, PGF2agr, U44069, and U46619 and is inhibited by PGE2 and isoproterenol.

Extracellular recording of electrical activity of the ampulla determined that electrical impulses traveled at a velocity of 2-5 mm/sec, that there was a reduction in conduction velocity towards ovulation, and that following ovulation the duration of the electrical bursts increased.

Note:
ACKNOWLEDGMENTS Supported in part by NIH grants HD09339 and P30 HD10202 (Smooth Muscle Core). The authors wish to thank Dr. A. A. Shaikh and the Southwest Research Foundation, San Antonio, TX, for the tissues used in this study.

Submitted on October 27, 1980
Accepted on March 20, 1981






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Copyright © 1981 by the Society for the Study of Reproduction.