Biol Reprod Keystone Symposia Conference on Frontiers in Reproductive Biology & Regulation of Fertility.
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Biology of Reproduction, Vol 25, 128-133, Copyright © 1981 by Society for the Study of Reproduction

Effect of Progestins on Implantation in the Western Spotted Skunk

RODNEY A. MEAD 1, P. W. CONCANNON 2, , and MARTHA McRAE 1

1 Department of Biological Sciences, University of Idaho, Moscow, Idaho 83843
2 Department of Physical Biology, New York State College of Veterinary Medicine, Cornell University, Ithaca, New York 14853


Intact or ovariectomized pregnant western spotted skunks were treated with progesterone administered in Silastic capsules or injected with medroxyprogesterone acetate (MPA) during the prolonged period of delayed implantation to determine whether either progestin would shorten the preimplantation period.

Plasma progesterone was elevated to levels which closely mimicked those previously observed at the time of implantation in both intact and ovariectomized skunks administered exogenous progesterone. However, this treatment failed to hasten implantation significantly in intact females, and nidation did not occur in any of the ovariectomized females. Progesterone was relatively effective in maintaining blastocyst viability for 120 days after ovariectomy. Treatment with MPA likewise failed to shorten the preimplantation period, and implantation did not occur in any of the ovariectomized MPA-treated skunks. Blastocyst survival was diminished in the latter group of animals.

These results indicate that increased progesterone secretion, which precedes renewed blastocyst development and implantation in this species, is not the sole hormonal trigger of these events.

Note:
ACKNOWLEDGMENTS We would like to thank Dr. Dale Everson for help with the statistical analyses, Ms. Ann Swannack and Mr. Raymond Saatman for their excellent technical assistance, and Dr. K. Kirton, Upjohn Co., for the Depo-Provera, MPA standard, and antiserum to MPA. This study was supported by a research grant (HD-06556) from NICHD.

Submitted on November 14, 1980
Accepted on March 30, 1981




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D. J. Hirzel, J. Wang, S.K. Das, S.K. Dey, and R.A. Mead
Changes in Uterine Expression of Leukemia Inhibitory Factor during Pregnancy in the Western Spotted Skunk
Biol Reprod, February 1, 1999; 60(2): 484 - 492.
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Copyright © 1981 by the Society for the Study of Reproduction.