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Biology of Reproduction, Vol 25, 171-180, Copyright © 1981 by Society for the Study of Reproduction

Effect of Centchroman on Preimplantation Embryonic Development and Tubal Transport in Mice

M. M. SINGH 1, and V. P. KAMBOJ 1

1 Division of Endocrinology, Central Drug Research Institute, Lucknow-226001, India


Administration of a single, oral dose of centchroman (2 mg/kg) within 24 h of mating prevented pregnancy in adult Swiss mice by "tube-locking" of the embryos at the ampullary-isthmic junction of the Fallopian tube. Well organized and apparently normal embryos were collected from the ampullary portion until Day 10 of pregnancy. The compound did not seem to produce any deleterious effect on the cleavage process, morula to blastocyst transformation, or shedding of zona pellucida. However, some delay was observed in the initiation as well as completion of these processes, and this could be due to environmental effects or to effects of the compound, or both. In addition, the compound also prevented decidualization of the uterine endometrium which consisted primarily of fibroblastic type cells.

Note:
ACKNOWLEDGMENTS This investigation was supported by grants from the Ministry of Health and Family Welfare, Government of India. The authors are grateful to Dr. Nitya Nand, Director, Central Drug Research Institute, Lucknow, for his keen interest in the study. Thanks are due to Messrs. R. P. Sinha and Kailash Narain for technical assistance and Mr. S. Banerji for illustrations.

Submitted on October 29, 1980
Accepted on February 18, 1981






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Copyright © 1981 by the Society for the Study of Reproduction.