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Biology of Reproduction, Vol 25, 227-234, Copyright © 1981 by Society for the Study of Reproduction

Vasoactive Intestinal Polypeptide (VIP) in the Human Female Reproductive Tract: Distribution and Motor Effects

G. HELM 1, B. OTTESEN 1, J. FAHRENKRUG 1, J.-J. LARSEN 1, C. OWMAN 1, N.-O. SJÖBERG 1, B. STOLBERG 1, F. SUNDLER 1, , and B. WALLES 1

1 Department of Obstetrics and Gynecology and Department of Histology, University of Lund, Sweden Institute of Medical Physiology B, University of Copenhagen Departments of Clinical Chemistry, Bispebjerg and Glostrup Hospitals Department of Pharmacology and Toxicology, Lundbeck and Co. and Department of Obstetrics and Gynecology, St. Elizabeth Hospital, Copenhagen, Denmark


The distribution and concentration of vasoactive intestinal polypeptide (VIP) in the human female genital tract were studied by means of immunohistochemistry and immunochemistry. Further, the effect of VIP (10-10-10-7M) on the mechanical activity of uterine smooth muscle was investigated. Generally, VIP immunoreactive nerve fibers were distributed among smooth muscle cells and around vessels. They were most abundant in the isthmic part of the Fallopian tube, the outer and inner ostium of the cervix, and in the vagina. The tissue concentration of VIP measured by immunochemistry was in good agreement with the immunohistochemical findings. VIP inhibited the spontaneous smooth muscle activity in strips from the Fallopian tube and the cervical region, but had no effect on strips from the uterine corpus. The data support the view that VIP may play a physiological role in the local control of smooth muscle motility in the human female reproductive tract.

Note:
ACKNOWLEDGMENTS This work was supported by grants from the Danish Hospital Foundation for Medical Research (Region Copenhagen, The Faroe Islands and Greenland: No. 78-13 and 79-16); Thomas Bartholins Fund; Novo’s Fund; the Danish Medical Research Council (No. 512-16111); the Faculty of Medicine, University of Lund; and the Swedish Medical Research Council (Grant no. 14X-5680). The skillful technical assistance of Susanne Bundgaard, Eva Engelbert, Kristine Fogelström, Barbro Gustavsson, Anita Hansen, Lene Poulsen, and Helle Trelde is gratefully acknowledged. Highly purified porcine VIP was kindly donated by Prof. V. Mutt, Karolinska Institutet, Stockholm, Sweden.

Submitted on October 20, 1980
Accepted on April 6, 1981




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Copyright © 1981 by the Society for the Study of Reproduction.