Biol Reprod Keystone Symposia Conference on Frontiers in Reproductive Biology & Regulation of Fertility.
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Biology of Reproduction, Vol 25, 298-302, Copyright © 1981 by Society for the Study of Reproduction

GnRH-Induced Regulation of GnRH Receptor Concentration in the Phenobarbital-Blocked Hamster

THOMAS E. ADAMS 1, and HAROLD G. SPIES 1

1 Reproductive Physiology, Oregon Regional Primate Research Center, Beaverton, Oregon 97006 and Department of Anatomy, University of Oregon Health Sciences Center, Portland, Oregon 97201


The effect of exogenous gonadotropin releasing hormone (GnRH) or ovine luteinizing hormone (oLH) on GnRH receptor binding characteristics was determined in the phenobarbital (Phen)-blocked proestrous hamster. Phenobarbital administration at 1130 h prevented the decline in GnRH receptor concentration that occurs normally during the afternoon of proestrus. In the Phenblocked hamster exogenous GnRH induced LH secretion, ovulation, and the decline in GnRH receptors.

Submitted on February 2, 1981
Accepted on April 14, 1981






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Copyright © 1981 by the Society for the Study of Reproduction.