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Biology of Reproduction, Vol 25, 303-306, Copyright © 1981 by Society for the Study of Reproduction

Regulation of Sertoli Cell Function by Thyrotropin

JAMES C. HUTSON 1, and DOUGLAS M. STOCCO 1

1 Department of Anatomy and Department of Biochemistry, Texas Tech University Health Sciences Center, Lubbock, Texas 79430


The effects of FSH on Sertoli cells are well documented; however, only recently has TSH been directly implicated in reproductive function. The purpose of this investigation was to test the effects of TSH on androgen binding protein (ABP) and plasminogen activator (PA) secretion by cultured rat Sertoli cells. The results of this investigation demonstrate similar dose-response patterns of ABP secretion with rat FSH and TSH, and human, ovine, and bovine TSH. No effect was observed with rat LH when used in identical doses. Rat TSH and FSH also stimulated PA secretion, but no similar effect was observed with rat LH. These finding further support the hypothesis that TSH has a direct role in male reproductive function, and indicate that Sertoli cells are the primary testicular site of action for this hormone.

Note:
ACKNOWLEDGMENTS The authors wish to acknowledge gratefully the technical assistance of Margaret Rodriguez and Debbie Dehaven, the secretarial assistance of Valeria Edwards, and the graphics preparation by Cindy Frisbie and David Dickey. The highly purified rat hormones were generously provided by NIAMDD, Rat Pituitary Hormone Distribution Program of NIH. The work was supported by grants from NIH (HD13990 and AM-23052) and NSF (PCM 7824391).

Submitted on January 26, 1981
Accepted on April 14, 1981






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Copyright © 1981 by the Society for the Study of Reproduction.