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Biology of Reproduction, Vol 25, 353-358, Copyright © 1981 by Society for the Study of Reproduction

Dose Response Analysis of GnRH Stimulation of hCG Release from Human Term Placenta

T. M. SILER-KHODR 1, and G. S. KHODR 1

1 Department of Obstetrics and Gynecology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas 78284


The release of immunoreactive alpha and beta human chorionic gonadotropin (agrhCG and betahCG) from placental explants in vitro was stimulated by GnRH in a dose-response fashion, but human chorionic somatomammotropin was not affected. The stimulation of agrhCG by GnRH (1, 2, or 5 µg/ml) occurred on Days 1-3 of culture, but this increase was dose-related only on Days 2 and 3. A dose-related stimulation of the betahCG release by GnRH was also observed on Days 1, 2, 3, 7, and 8. In addition, increased release of betahCG was effected on Day 4, using the highest dose of GnRH studied (5 µg/ml).

The cumulative release of agrhCG during the 8 days of culture was not stimulated in a dose-response fashion by GnRH, while the increased cumulative release of betahCG was dose-related.

Note:
ACKNOWLEDGMENTS The excellent technical assistance of J. Rhode and the secretarial assistance of Ms. G. Small and S. Huegele are gratefully acknowledged.

Submitted on November 7, 1980
Accepted on May 4, 1981




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Copyright © 1981 by the Society for the Study of Reproduction.