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Biology of Reproduction, Vol 25, 370-374, Copyright © 1981 by Society for the Study of Reproduction

Role of Prolactin in the Lactational Amenorrhea of the Rhesus Monkey (Macaca mulatta)

E. SCHALLENBERGER 1, D. W. RICHARDSON 1, , and E. KNOBIL 1

1 Department of Physiology, University of Pittsburgh, School of Medicine, Pittsburgh, Pennsylvania 15261


The role of prolactin in suckling-induced suppression of gonadotropmn secretion was investigated in postpartum rhesus monkeys treated with bromocriptine, some of which were allowed to suckle their young while others were not. Serum prolactin (PRL) was suppressed in all animals. The postpartum rise in the basal levels of luteinizing hormone (LH) and the response to the positive feedback action of estradiol were delayed in the suckled monkeys when compared with their nonsuckled controls. The inhibition of LH secretion was more pronounced than that of follicle stimulating hormone (FSH). These findings permit the conclusion that hyperprolactinemia may not entirely account for the inhibition of gonadotropin secretion during lactation and that sensory inputs associated with suckling may affect the hypothalamic control of gonadotropin secretion by some other mechanism.

Note:
ACKNOWLEDGMENTS The authors express their gratitude to Sandoz Pharmaceuticals, East Hanover, NJ, for the generous supply of bromocriptine and to C. Stehle, M. Forston, and our Animal Care Staff for their expert technical assistance.

Submitted on February 18, 1981
Accepted on May 13, 1981




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Copyright © 1981 by the Society for the Study of Reproduction.