Biol Reprod Keystone Symposia Conference on Frontiers in Reproductive Biology & Regulation of Fertility.
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Biology of Reproduction, Vol 25, 549-554, Copyright © 1981 by Society for the Study of Reproduction

In vivo Uptake of 125I-Relaxin in the Guinea Pig

GEOFFREY S. GATES 1, JEFFREY J. FLYNN 1, ROBERT J. RYAN 1, , and O. DAVID SHERWOOD 2

1 Department of Cell Biology, Mayo Medical School, Rochester, Minnesota 55901
2 Department of Physiology, University of Illinois, Urbana, Illinois 61801


125I-Relaxin uptake in the guinea pig showed a time-dependent concentration in the uterine cervix and symphysis pubis. Binding in target tissues was displaceable by a concurrently administered excess of unlabeled hormone. Exogenous estrogen priming in the virgin female and retired breeder was unnecessary to demonstrate displaceable binding and concentration in the uterine cervix, while priming decreased displaceable binding in the uterine horns compared with similar unprimed animals. No displaceable binding or concentration was found in other tissues, including connective tissues. Thus, the uterus and symphysis pubis appear to be the principal if not the sole target tissues for relaxin.

Note:
ACKNOWLEDGMENTS The help of Dr. Andrew LaBarbera and Mrs. Elizabeth Bergert are gratefully acknowledged. This work was supported by NIH Grant HD 9140 and the Mayo Foundation.

Submitted on December 1, 1980
Accepted on June 3, 1981






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Copyright © 1981 by the Society for the Study of Reproduction.