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Biology of Reproduction, Vol 25, 555-559, Copyright © 1981 by Society for the Study of Reproduction

Inhibitory Effect of Estradiol-17• on Human Chorionic Gonadotropin-Induced Increment of Testicular Blood Flow and Plasma Testosterone Concentration in Rats

J. E. DAMBER 1, G. SELSTAM 1, , and J. WANG 1

1 Department of Physiology, University of Umeå, 901 87 Umea, Sweden


The effects of human chorionic gonadotropin (hCG) and estradiol-17beta (E2) on testicular blood flow and plasma testosterone concentrations were measured in rats. Injection of 100 IU hCG 20-24 h prior to experiment resulted in a significant rise in testicular blood flow and plasma testosterone concentration. Daily treatment with 50 µg E2 for 5 days did not affect testicular blood flow but induced a significant depression of plasma testosterone concentration. However, E2 treatment did partly diminish the stimulatory effect of hCG on both testicular blood flow and the concentration of testosterone in plasma. It was concluded that blood flow changes are involved in the effect of hCG on testicular endocrine function and that E2 can partly inhibit these effects.

Note:
ACKNOWLEDGMENTS This study was supported by grants from the Swedish Medical Research Council (Project No. B80-05653), Jubileumklinikens i Umeå Forskningsfond, and the Medical Faculty of the University of Umeå, Sweden. Skillful technical assistance was provided by Mr. I. Nilsson, Miss A. Knutsson, and Miss B. Siverwall.

Submitted on March 24, 1981
Accepted on June 8, 1981






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Copyright © 1981 by the Society for the Study of Reproduction.