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Biology of Reproduction, Vol 25, 1149-1158, Copyright © 1981 by Society for the Study of Reproduction

Hormonally Responsive Areas of the Reproductive System of the Male Guinea Pig. II. Effects of Estrogens

J. DAVIES 1, and B. J. DANZO 1

1 Department of Anatomy, Department of Obstetrics and Gynecology, and Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232


The administration of 2.5 µg of diethylstilbestrol (DES) to intact male guinea pigs for 10 or 30 days resulted in cytological changes in their reproductive tracts. These changes were most marked in those structures derived from the urogenital sinus. Treatment with DES affected both the epithelium and the stromal components of the tissues to a varying degree. Mucification of the epithelium of the distal segments of the vasa deferentia, seminal vesicles, and the sinus portion of the uterus musculinus was observed. Proliferation of the sinus epithelium of the common ejaculatory chamber also occurred, being most marked over the verumontanum. There was also proliferation and squamous metaplasia of the same areas after 30 days administration. The secretory portions of the seminal vesicles, prostate, and coagulating glands, and the vas deferens throughout its length, underwent atrophy and squamous metaplasia. After 30 days of DES treatment, atrophy of the epididymis was observed; the distal portion of the cauda epididymidis was most affected. Atrophy of the spermatogenic epithelium was noted in the animals that received DES for 30 days. An increase in the ground substance of the stroma of the verumontanum was also observed. Hypertrophy of the smooth muscle of the verumontanum and of the seminal vesicles was observed in some animals after 30 days of treatment with DES. The administration of estradiol (2.5 µg/day for 30 days) or estradiol benzoate (10 µg/day for 10 days) was less effective than DES in causing the above lesions. This indicates that the phenomena observed are dependent upon the nature of the estrogenic stimulus as well as on the dose and duration of the treatment.

Note:
ACKNOWLEDGMENTS The research was supported by NIH Grants HD 11607, HD 05797 (Population Center), and RR 05424-18 (Biomedical Research Support Grant), and a grant from the Eli Lilly Company, Inc. of Indianapolis. The authors also wish to express their thanks to Ms. Brenda Evans for technical assistance and the photographic work, and to Ms. Vera Henley for help with the preparation of the manuscript.

Submitted on June 24, 1980
Accepted on August 25, 1981




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[Abstract] [Full Text] [PDF]


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Copyright © 1981 by the Society for the Study of Reproduction.