Biol Reprod Lalor Postdoctoral Fellowships -- Application Deadline January 15, 2009
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Leadem, C. A.
Right arrow Articles by Blask, D. E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Leadem, C. A.
Right arrow Articles by Blask, D. E.
Agricola
Right arrow Articles by Leadem, C. A.
Right arrow Articles by Blask, D. E.

Biology of Reproduction, Vol 26, 413-421, Copyright © 1982 by Society for the Study of Reproduction

ARTICLES

A comparative study of the effects of the pineal gland on prolactin synthesis, storage and release in male and female blind-anosmic rats

CA Leadem and DE Blask

The effect of the pineal gland on Prl synthesis, storage and release were compared in male and female rats 8 weeks after prepubertal blinding and olfactory bulbectomy. Anterior pituitary weight was reduced in blind-anosmic female and male rats. This was correlated with a decreased pituitary DNA content in male blind-anosmic rats. Pinealectomy partially reversed these effects. Prl release, as assessed by monitoring serum Prl levels, was significantly reduced in both male and female blind-anosmic rats. Pinealectomy reversed the effect in females but not males. Prl storage was estimated by measuring the levels of Prl in the anterior pituitary in vivo. Pituitary Prl content was significantly decreased in both male and female blind-anosmic rats. Pinealectomy prevented this reduction in Prl storage. Finally, Prl synthesis was evaluated by measuring the incorporation of [3H] leucine into Prl during 5 hours of pituitary incubation in vitro. Prl synthesis was decreased by 45% in blind-anosmic female rats and 34% in blind- anosmic male rats. Once again these effects were due to the pineal because pinealectomy fully ameliorated the influences of blinding and olfactory bulbectomy on Prl synthesis. From these data we conclude that the pineal inhibits Prl synthesis, storage and release in both female and male blind-anosmic rats.




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1982 by the Society for the Study of Reproduction.