Biol Reprod Keystone Symposia Conference on Frontiers in Reproductive Biology & Regulation of Fertility.
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Biology of Reproduction, Vol 28, 134-141, Copyright © 1983 by Society for the Study of Reproduction

ARTICLES

Effects of 2(p-biphenyl) propionic acid on the life span of the corpus luteum of pseudopregnant and cyclic rats

RL Cochrane, JG Powell Jr, NR Mason and RP Rathmacher

A potent prostaglandin synthesis inhibitor (cyclooxygenase inhibitor), 2(p-biphenyl) propionic acid (BPPA), was administered subcutaneously at the dose of 1 mg twice daily to pseudopregnant and cyclic rats. It was found to prolong the duration of pseudopregnancy by about 10 days and to have little or no effect on estrous cycle length. It did not block ovulation and had little effect on ovulation rate in cyclic rats. BPPA was given to pseudopregnant rats in two trials (one in October-December and the other in March-May) to determine its effect on ovarian weight and plasma progesterone concentration on Days 14, 15 and 16 (Day 0=day of induction of pseudopregnancy). BPPA significantly (P less than 0.001) increased plasma progesterone concentration and reduced ovarian weight. The present data support the hypothesis that prostaglandins cause the normal functional demise of the corpora lutea of pseudopregnancy in the intact rat, and that depressing their synthesis will prolong the functional life span of the corpora lutea.




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Copyright © 1983 by the Society for the Study of Reproduction.