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Biology of Reproduction, Vol 3, 229-235, Copyright © 1970 by Society for the Study of Reproduction

A Uterine Fluid-Mediated Sperm-Inhibitory System

DONALD C. SMITH 1, and SEYMOUR J. KLEBANOFF 1

1 USPHS Hospital, Seattle, 98114, and the Departments of Medicine and Obstetrics and Gynecology, University of Washington School of Medicine, Seattle, Washington 98105


Uterine fluid from estrogen-primed immature or mature ovariectomized rats has sperminhibitory activity when combined with H2O2 and either iodide or thiocyanate ions as measured by a loss of motility and by a decrease in pyruvate oxidation. The uterine fluid can be replaced by lactoperoxidase or myeloperoxidase which suggests that the sperm-inhibitory effect of uterine fluid is due to its peroxidase content. The uterine fluidmediated sperm-inhibitory system is inhibited by catalase and by a number of lowmolecular-weight compounds such as azide, reduced glutathione, cysteine, ergothioneine, and ascorbic acid. Heat-stable, low-molecular-weight inhibitors are found in seminal plasma and, to a lesser degree, in uterine fluid.

Submitted on August 4, 1970






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Copyright © 1970 by the Society for the Study of Reproduction.