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Biology of Reproduction, Vol 3, 236-242, Copyright © 1970 by Society for the Study of Reproduction

The Source of H2O2 for the Uterine Fluid-Mediated Sperm-Inhibitory System

SEYMOUR J. KLEBANOFF 1, and DONALD C. SMITH 1

1 USPHS Hospital, Seattle, 98114, and the Departments of Medicine and Obstetrics and Gynecology, University of Washington School of Medicine, Seattle, Washington 98105


Lactobacillus acidophilus, a H2O2-generating organism commonly found in the vaginal canal, can substitute for reagent H2O2 in the uterine fluid-mediated sperm-inhibitory system. Lactobacilli also can inhibit sperm motility by producing a fall in pH. Spermatozoa form H2O2 particularly in the presence of certain amino acids (L-phenylalanine, L-tryptophane, L-methionine, L-tyrosine, L-monoiodotyrosine, L-diiodotyrosine, L-dibromotyrosine). The H2O2 formed by spermatozoa in the presence of L-phenylalanine can be utilized as a component of the uterine fluid-iodide (or thiocyanate)-H2O2 sperm-inhibitory system. The presence of a peroxidase-mediated sperm-inhibitory system in human secretions is considered.

Submitted on August 4, 1970






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Copyright © 1970 by the Society for the Study of Reproduction.