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Biology of Reproduction, Vol 3, 283-292, Copyright © 1970 by Society for the Study of Reproduction
1 Department of Anatomy, McGill University, Montreal, Canada The proliferative activity of epithelial cells lining the epididymis as judged from labeling
indices in 3H-thymidine-injected animals and from mitotic indices was evaluated in three
groups of adult albino rats, respectively, aged 2.5, 4, and 12 months. The labeling indices of principal and basal cells were relatively high in 2.5-month-old
rats (2.2% of principal cells and 1.4% of basal cells for the whole epididymis) but low
(below 0.6%) in 4-and 12-month-old animals. In the 2.5-month-old animals the cells labeled
with 3H-thymidine stayed within the epithelium for a long period of time thereafter (up
to 50 days when the experiment was terminated). There was no appreciable labeling of the
nonstereociliated narrow columnar and light cells and no sign of cell loss. Mitotic indices
were appreciable in 2.5-month-old rats but insignificant in older animals. Mitotic indices
obtained from 4-month-old animals injected with colchicine were similar to that of noncolchicine-injected animals. These data indicated that in sexually mature but young adult
rats growth was still taking place in the epididymis. In older rats growth of the epididymis
continued but at a considerably lower rate. In these animals the low mitotic and labeling
indices of the epididymal epithelial cells classified this cell population amongst the expanding rather than amongst the renewing ones. No holocrine secretion must therefore take
place in the epididymis of adult rats.
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