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Biology of Reproduction, Vol 31, 984-988, Copyright © 1984 by Society for the Study of Reproduction

ARTICLES

Sex differences in the cyclic adenosine 3':5'-monophosphate and growth hormone response to growth hormone-releasing factor in vitro

MJ Cronin and AD Rogol

Human pancreas tumor growth hormone-releasing factor (hpGRF) induced more cellular cyclic adenosine 3':5'-monophosphate (AMP) accumulation and growth hormone release from male than female rat anterior pituitaries in vitro. This was reflected in a change in maximal levels achieved (efficacy) rather than potency, and was not an exclusive effect of hpGRF peptide; prostaglandin E2 also exhibited these effects. These data suggest that the origin of the larger spontaneous peak growth hormone levels in male rats may be within the anterior pituitary gland.




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Copyright © 1984 by the Society for the Study of Reproduction.