Biol Reprod Keystone Symposia Conference on Frontiers in Reproductive Biology & Regulation of Fertility.
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Biology of Reproduction, Vol 32, 556-560, Copyright © 1985 by Society for the Study of Reproduction

ARTICLES

Induction of cell-mediated cytotoxic immunity to sperm-specific lactate dehydrogenase-C4 in SJL/J female mice

JA Shelton and E Goldberg

SJL/J female mice were tested for a cell-mediated cytotoxic response to sperm-specific lactate dehydrogenase C4 (LDH-C4). We demonstrated this response with a 51chromium release assay. Mouse LDH-C4 was coupled to EL-4 tumor cells. These cells were then labeled with 51Cr and mixed with splenocytes from LDH-C4-immune and -nonimmune mice. Specific lysis of the tumor cells by splenocytes from LDH-C4-immune mice was detected at 7 days and 14 days following a single footpad immunization. Since LDH-C4 is present on the surface of sperm, these results support the suggestion that cytotoxic removal of sperm from the female reproductive tract is one of the mechanisms whereby fertility is reduced following immunization with this enzyme.


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J.-J. Chang, J.-P. Peng, Y. Yang, J.-L. Wang, and L. Xu
Study on the antifertility effects of the plasmid DNA vaccine expressing partial brLDH-C4'
Reproduction, January 1, 2006; 131(1): 183 - 192.
[Abstract] [Full Text] [PDF]


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Copyright © 1985 by the Society for the Study of Reproduction.